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Article

PIK3CA, HRAS and PTEN in human papillomavirus positive oropharyngeal squamous cell carcinoma.

BMC cancer - 17 Dec 2013

Chiosea Simion I, Grandis Jennifer R, Lui Vivian W Y, Diergaarde Brenda, Maxwell Jessica H, Ferris Robert L, Kim Seungwon W, Luvison Alyssa, Miller Megan, Nikiforova Marina N

Abstract excerpt

BACKGROUND: Recent genomic evidence suggests frequent phosphatidylinositide 3-kinase (PI3K) pathway activation in human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma. Mutations/amplification of the gene encoding p110α catalytic subunit of phosphoinositide 3-kinase (PIK3CA), loss of phosphatase and tensin homolog (PTEN) and HRAS mutations are known to activate PI3K pathway. METHODS AND...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24341335
DOI: 10.1186/1471-2407-13-602
PMCID: PMC3878565

Genes

HRAS
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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