Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2015

Chung C H, Guthrie V B, Masica D L, Tokheim C, Kang H, Richmon J, Agrawal N, Fakhry C, Quon H, Subramaniam R M, Zuo Z, Seiwert T, Chalmers Z R, Frampton G M, Ali S M, Yelensky R, Stephens P J, Miller V A, Karchin R, Bishop J A

Abstract excerpt

BACKGROUND: To determine genomic alterations in head and neck squamous cell carcinoma (HNSCC) using formalin-fixed, paraffin-embedded (FFPE) tumors obtained through routine clinical practice, selected cancer-related genes were evaluated and compared with alterations seen in frozen tumors obtained through research studies. PATIENTS AND METHODS: DNA samples obtained from 252 FFPE HNSCC were analyzed using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Fixatives

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Formaldehyde

Share to Head and Neck Neoplasms

Share to Human Papillomavirus DNA Tests

Share to Paraffin Embedding

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tissue Fixation

Source

Open in PubMed Open full text

Identifiers

PMID: 25712460
DOI: 10.1093/annonc/mdv109
PMCID: PMC4516044

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.PMID 25712460Read ↗

Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas.Semantic proximity Read ↗

Sequencing the head and neck cancer genome: implications for therapy.Semantic proximity Read ↗

Incorporation of Next-Generation Sequencing into Routine Clinical Care to Direct Treatment of Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

Comprehensive genomic profiling of head and neck squamous cell carcinoma reveals FGFR1 amplifications and tumour genomic alterations burden as prognostic biomarkers of survival.Semantic proximity Read ↗

Molecular heterogeneity of head and neck squamous cell carcinoma defined by next-generation sequencing.Semantic proximity Read ↗

Therapeutic Insights from Genomic Studies of Head and Neck Squamous Cell CarcinomasSemantic proximity Read ↗

Molecular landscape of head and neck cancer and implications for therapySemantic proximity Read ↗

Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).Semantic proximity Read ↗

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapiesSemantic proximity Read ↗

Comprehensive genomic characterization of head and neck squamous cell carcinomas.Semantic proximity Read ↗

Genomic insights into head and neck cancerSemantic proximity Read ↗

Investigating the Feasibility of Targeted Next-Generation Sequencing to Guide the Treatment of Head and Neck Squamous Cell Carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.