Article
Genome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA Pathway.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2015
Lou Hong, Villagran Guillermo, Boland Joseph F, Im Kate M, Polo Sarita, Zhou Weiyin, Odey Ushie, Juárez-Torres Eligia, Medina-Martínez Ingrid, Roman-Basaure Edgar, Mitchell Jason, Roberson David, Sawitzke Julie, Garland Lisa, Rodríguez-Herrera Maria, Wells David, Troyer Jennifer, Pinto Francisco Castillo, Bass Sara, Zhang Xijun, Castillo Miriam, Gold Bert, Morales Hesler, Yeager Meredith, Berumen Jaime, Alvirez Enrique, Gharzouzi Eduardo, Dean Michael
Abstract excerpt
PURPOSE: Cervical cancer is one of the most common causes of cancer mortality for women living in poverty, causing more than 28,000 deaths annually in Latin America and 266,000 worldwide. To better understand the molecular basis of the disease, we ascertained blood and tumor samples from Guatemala and Venezuela and performed genomic characterization. EXPERIMENTAL DESIGN: We performed human papillomavirus (HPV)...
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