Article

Impact of PI3K pathway alterations on response to immune checkpoint inhibitors in HPV-negative head and neck squamous cell carcinoma

2024-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway (PI3K pathway) is a major intracellular regulatory pathway commonly involved in cancer survival, proliferation, migration, and metabolism. Activating mutations and amplifications of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ( PIK3CA ) are frequent genomic features of head and neck...

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Literature Corpus work: fbf4c9f6-1c29-5e25-84db-9c0bc5b8a2e0
DOI: 10.1101/2024.07.02.601738

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