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Article

Recurrent PIK3CA-E545K mutation promotes cervical cancer growth and invasion via AKT/mTOR signaling.

Molecular genetics and genomics : MGG - 7 Aug 2026

Huang Congxiu, Zhang Wei, Ma Xiaoyu, Li Xuefeng, Sun Xiaoge

Abstract excerpt

Cervical cancer remains a leading cause of cancer-related morbidity and mortality among women worldwide. Although genomic alterations in oncogenic signaling pathways have been implicated in cervical carcinogenesis, the functional impact of recurrent driver mutations remains incompletely understood. Whole-exome sequencing was performed on paired tumor and matched non-tumor tissues from 61 patients to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

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Share to Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 42562966
DOI: 10.1007/s00438-026-02495-z

Genes

PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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