Article
High frequency of activating PIK3CA mutations in human papillomavirus-positive oropharyngeal cancer.
JAMA otolaryngology-- head & neck surgery - 1 Jun 2013
Nichols Anthony C, Palma David A, Chow Winsion, Tan Susan, Rajakumar Chandheeb, Rizzo Giananthony, Fung Kevin, Kwan Keith, Wehrli Brett, Winquist Eric, Koropatnick James, Mymryk Joe S, Yoo John, Barrett John W
Abstract excerpt
IMPORTANCE: Large-scale whole-exome sequencing studies of head and neck squamous cell carcinoma (HNSCC) have established that the disease is dominated by frequent mutations in tumor suppressor genes with rare activating mutations in oncogenes that would be easily targetable with molecular agents. There was evidence in these reports, however, that activating mutations in phosphoinositide 3-kinase catalytic subunit...
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