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Article

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.

Nature communications - 6 Mar 2014

Klimovskaia Ilnaz M, Young Clifford, Strømme Caroline B, Menard Patrice, Jasencakova Zuzana, Mejlvang Jakob, Ask Katrine, Ploug Michael, Nielsen Michael L, Jensen Ole N, Groth Anja

Abstract excerpt

During DNA replication, nucleosomes are rapidly assembled on newly synthesized DNA to restore chromatin organization. Asf1, a key histone H3-H4 chaperone required for this process, is phosphorylated by Tousled-like kinases (TLKs). Here, we identify TLK phosphorylation sites by mass spectrometry and dissect how phosphorylation has an impact on human Asf1 function. The divergent C-terminal tail of Asf1a is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24598821
DOI: 10.1038/ncomms4394
PMCID: PMC3977046

Genes

HIRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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