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Article

Molecular basis of Tousled-Like Kinase 2 activation.

Nature communications - 28 Jun 2018

Mortuza Gulnahar B, Hermida Dario, Pedersen Anna-Kathrine, Segura-Bayona Sandra, López-Méndez Blanca, Redondo Pilar, Rüther Patrick, Pozdnyakova Irina, Garrote Ana M, Muñoz Inés G, Villamor-Payà Marina, Jauset Cristina, Olsen Jesper V, Stracker Travis H, Montoya Guillermo

Abstract excerpt

Tousled-like kinases (TLKs) are required for genome stability and normal development in numerous organisms and have been implicated in breast cancer and intellectual disability. In humans, the similar TLK1 and TLK2 interact with each other and TLK activity enhances ASF1 histone binding and is inhibited by the DNA damage response, although the molecular mechanisms of TLK regulation remain unclear. Here we describe...

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Source

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Identifiers

PMID: 29955062
DOI: 10.1038/s41467-018-04941-y
PMCID: PMC6023931

Genes

TLK2
TLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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