Article

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction

2024-04-26

Abstract excerpt

Tousled-like kinases 1 and 2 (TLK1 and 2) are cell cycle-regulated serine/threonine kinases that are involved in multiple biological processes. Mutation of TLK1 and 2 confer neurodegenerative diseases. Recent studies demonstrate that TLK1 and 2 are involved in DNA repair. However, there is no direct evidence that TLK1 and 2 function at DNA damage sites. Here, we show that both TLK1 and TLK2 are hyper-autophosphory...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3c2d058d-70fe-521a-a66e-58b65da2ba9f
DOI: 10.1101/2024.04.22.590659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interactionDOI 10.1101/2024.04.22.590659Read

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction.Semantic proximity Read

Molecular basis of Tousled-Like Kinase 2 activation.Semantic proximity Read

Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signalingSemantic proximity Read

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitorsSemantic proximity Read

Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpointSemantic proximity Read

The Tousled-like kinases regulate genome and epigenome stability: implications in development and diseaseSemantic proximity Read

CHK2-FOXK axis promotes transcriptional control of autophagy programs.Semantic proximity Read

Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.Semantic proximity Read

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.Semantic proximity Read

DNA damage-induced phosphorylation of the human telomere-associated protein TRF2Semantic proximity Read

Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.Semantic proximity Read

Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.Semantic proximity Read