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Article

Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells.

The Journal of biological chemistry - 12 May 2006

Sanematsu Fumiyuki, Takami Yasunari, Barman Hirak Kumar, Fukagawa Tatsuo, Ono Tatsuya, Shibahara Kei-Ichi, Nakayama Tatsuo

Abstract excerpt

Asf1 (anti-silencing function 1), a well conserved protein from yeast to humans, acts as a histone chaperone and is predicted to participate in a variety of chromatin-mediated cellular processes. To investigate the physiological role of vertebrate Asf1 in vivo, we generated a conditional Asf1-deficient mutant from chicken DT40 cells. Induction of Asf1 depletion resulted in the accumulation of cells in S phase...

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Source

Identifiers

PMID: 16537536
DOI: 10.1074/jbc.M511590200

Genes

HIRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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