Article

Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signaling

2019-04-28

Abstract excerpt

The Tousled like kinases 1 and 2 (TLK1/2) control histone deposition through the ASF1 histone chaperones and are regulated by the DNA damage response. Depletion of TLK activity caused replication stress, increased chromosomal instability and cell arrest or death. Here, we show that stalled forks in TLK depleted cells are processed by BLM, SAMHD1 and the MRE11 nuclease to generate ssDNA and activate checkpoint sign...

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Literature Corpus work: 4a857287-1835-5647-af08-c984e95bd28b
DOI: 10.1101/621409

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