Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction.

Nucleic acids research - 8 Feb 2025

West Kirk L, Nguyen Tram T N, Tengler Kyle A, Kreiling Natasha, Raney Kevin D, Ghosal Gargi, Leung Justin W

Abstract excerpt

Tousled-like kinases 1 and 2 (TLK1 and 2) are cell cycle-regulated serine/threonine kinases that are involved in multiple biological processes. Mutation of TLK1 and 2 confer neurodegenerative diseases. Recent studies demonstrate that TLK1 and 2 are involved in DNA repair. However, there is no direct evidence that TLK1 and 2 function at DNA damage sites. Here, we show that both TLK1 and TLK2 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Mutation

Share to Phosphorylation

Share to Proliferating Cell Nuclear Antigen

Share to Protein Binding

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 39727191
DOI: 10.1093/nar/gkae1279
PMCID: PMC11879137

Genes

TLK1
PCNA
PIP
TLK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction.PMID 39727191Read ↗

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interactionSemantic proximity Read ↗

Molecular basis of Tousled-Like Kinase 2 activation.Semantic proximity Read ↗

Tousled-like kinase activity is required for transcriptional silencing and suppression of innate immune signalingSemantic proximity Read ↗

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitorsSemantic proximity Read ↗

Human Tousled like kinases are targeted by an ATM‐ and Chk1‐dependent DNA damage checkpointSemantic proximity Read ↗

The Tousled-like kinases regulate genome and epigenome stability: implications in development and diseaseSemantic proximity Read ↗

CHK2-FOXK axis promotes transcriptional control of autophagy programs.Semantic proximity Read ↗

Functional analysis of TLK2 variants and their proximal interactomes implicates impaired kinase activity and chromatin maintenance defects in their pathogenesis.Semantic proximity Read ↗

Tousled-like kinases phosphorylate Asf1 to promote histone supply during DNA replication.Semantic proximity Read ↗

DNA damage-induced phosphorylation of the human telomere-associated protein TRF2Semantic proximity Read ↗

Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.Semantic proximity Read ↗

Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.