Article
Sequence-based polymorphisms in the mitochondrial D-loop and potential SNP predictors for chronic dialysis.
PloS one - 1 Jan 2012
Chen Jin-Bor, Yang Yi-Hsin, Lee Wen-Chin, Liou Chia-Wei, Lin Tsu-Kung, Chung Yueh-Hua, Chuang Li-Yeh, Yang Cheng-Hong, Chang Hsueh-Wei
Abstract excerpt
BACKGROUND: The mitochondrial (mt) displacement loop (D-loop) is known to accumulate structural alterations and mutations. The aim of this study was to investigate the prevalence of single nucleotide polymorphisms (SNPs) within the D-loop among chronic dialysis patients and healthy controls. METHODOLOGY AND PRINCIPAL FINDINGS: We enrolled 193 chronic dialysis patients and 704 healthy controls. SNPs were...
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