Article
Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with the kidney survival time in chronic kidney disease patients.
Renal failure - 1 Feb 2015
Xu Jinsheng, Guo Zhanjun, Bai Yaling, Zhang Junxia, Cui Liwen, Zhang Huiran, Zhang Shenglei, Ai Xiaolu
Abstract excerpt
BACKGROUND: The mitochondrial displacement loop (D-loop) is known to accumulate mutations and SNPs at a higher frequency than other regions of mitochondrial DNA (mtDNA). We had identified chronic kidney disease (CKD) risk-associated SNPs in the D-loop of CKD patients previously. In this study, we investigated the association of SNPs in the D-loop of mtDNA with the kidney survival of CKD. METHODS: The D-loop...
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