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Mitochondrial genetic variation and risk of chronic kidney disease and acute kidney injury in UK Biobank participants.

Human genetics - 1 Feb 2024

Jotwani Vasantha, Yang Stephanie Y, Thiessen-Philbrook Heather, Parikh Chirag R, Katz Ronit, Tranah Gregory J, Ix Joachim H, Cummings Steve, Waikar Sushrut S, Shlipak Michael G, Sarnak Mark J, Parikh Samir M, Arking Dan E

Abstract excerpt

Experimental models suggest an important role for mitochondrial dysfunction in the pathogenesis of chronic kidney disease (CKD) and acute kidney injury (AKI), but little is known regarding the impact of common mitochondrial genetic variation on kidney health. We sought to evaluate associations of inherited mitochondrial DNA (mtDNA) variation with risk of CKD and AKI in a large population-based cohort. We...

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Identifiers

PMID: 38349571
DOI: 10.1007/s00439-023-02615-4
PMCID: PMC10881785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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