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Article

ATM specifically mediates repair of double-strand breaks with blocked DNA ends

27 Feb 2014

Abstract excerpt

Ataxia telangiectasia is caused by mutations in ATM and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the DNA-damage response. The role of ATM as a key regulator of signalling following DNA double-strand breaks (DSBs) has been dissected in extraordinary detail, but the impact of this process on DSB repair still remains controversial. Here we develop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24572510
DOI: 10.1038/ncomms4347

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