Article
ATM signaling and genomic stability in response to DNA damage.
Mutation research - 6 Jan 2005
Lavin Martin F, Birrell Geoff, Chen Philip, Kozlov Sergei, Scott Shaun, Gueven Nuri
Abstract excerpt
DNA double strand breaks represent the most threatening lesion to the integrity of the genome in cells exposed to ionizing radiation and radiomimetic chemicals. Those breaks are recognized, signaled to cell cycle checkpoints and repaired by protein complexes. The product of the gene (ATM) mutated in the human genetic disorder ataxia-telangiectasia (A-T) plays a central role in the recognition and signaling of DNA...
Topics
- Animals
- Ataxia Telangiectasia
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- DNA Damage
- DNA-Binding Proteins
- Genomic Instability
- Humans
- Mutation
- Neoplasms
- Protein Serine-Threonine Kinases