Article
ATM prevents DSB formation by coordinating SSB repair and cell cycle progression.
Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015
Khoronenkova Svetlana V, Dianov Grigory L
Abstract excerpt
DNA single-strand breaks (SSBs) arise as a consequence of spontaneous DNA instability and are also formed as DNA repair intermediates. Their repair is critical because they otherwise terminate gene transcription and generate toxic DNA double-strand breaks (DSBs) on replication. To prevent the formation of DSBs, SSB repair must be completed before DNA replication. To accomplish this, cells should be able to detect...
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