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Article

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining

15 Jul 2010

Abstract excerpt

The human disorder ataxia telangiectasia (AT), which is characterized by genetic instability and neurodegeneration, results from mutation of the ataxia telangiectasia mutated (ATM) kinase. The loss of ATM leads to cell cycle checkpoint deficiencies and other DNA damage signaling defects that do not fully explain all pathologies associated with A-T including neuronal loss. In addressing this enigma, we find here...

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PMID: 20647759
DOI: 10.4161/cc.9.14.12363

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ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joiningPMID 20647759Read ↗

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