Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks

21 Aug 2020

Abstract excerpt

Two DNA repair pathways operate at DNA double strand breaks (DSBs): non-homologous end-joining (NHEJ), that requires two adjacent DNA ends for ligation, and homologous recombination (HR), that resects one DNA strand for invasion of a homologous duplex. Faithful repair of replicative single-ended DSBs (seDSBs) is mediated by HR, due to the lack of a second DNA end for end-joining. ATM stimulates resection at such...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32890395
DOI: 10.1093/nar/gkaa723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaksPMID 32890395Read ↗

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaksSemantic proximity Read ↗

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairSemantic proximity Read ↗

ATM specifically mediates repair of double-strand breaks with blocked DNA endsSemantic proximity Read ↗

Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair processSemantic proximity Read ↗

DNA-PKcs and ATM co-regulate DNA double-strand break repair.Semantic proximity Read ↗

Structural insights into the role of DNA-PK as a master regulator in NHEJSemantic proximity Read ↗

The DNA‐dependent protein kinase: the director at the endSemantic proximity Read ↗

ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joiningSemantic proximity Read ↗

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage ResponseSemantic proximity Read ↗

SV40 Utilizes ATM Kinase Activity to Prevent Non-homologous End Joining of Broken Viral DNA Replication ProductsSemantic proximity Read ↗

ATR signaling at a glanceSemantic proximity Read ↗

DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.