Article

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

2018-05-24

Abstract excerpt

<h4>Summary</h4> Mutations in the ATM tumor suppressor confer hypersensitivity to DNA-damaging agents. To explore genetic resistance mechanisms, we performed genome-wide CRISPR-Cas9 screens in cells treated with the DNA topoisomerase poison topotecan. Thus, we establish that loss of terminal components of the non-homologous end-joining (NHEJ) machinery or the BRCA1-A complex specifically confers topotecan resist...

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Literature Corpus work: e086c93c-6247-57e0-9df6-8607b3d00896
DOI: 10.1101/330043

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