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Article

Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury.

Journal of the American Heart Association - 26 Feb 2014

Tzeng Huei-Ping, Evans Sarah, Gao Feng, Chambers Kari, Topkara Veli K, Sivasubramanian Natarajan, Barger Philip M, Mann Douglas L

Abstract excerpt

BACKGROUND: We have demonstrated that tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2), a scaffolding protein common to TNF receptors 1 and 2, confers cytoprotection in the heart. However, the mechanisms for the cytoprotective effects of TRAF2 are not known. METHODS/RESULTS: Mice with cardiac-restricted overexpression of low levels of TRAF2 (MHC-TRAF2LC) and a dominant negative TRAF2 (MHC-TRAF2DN)...

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Identifiers

PMID: 24572254
DOI: 10.1161/JAHA.113.000662
PMCID: PMC3959693

Genes

TRAF2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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