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Article

Telomere attrition and Chk2 activation in human heart failure

17 Apr 2003

Abstract excerpt

The "postmitotic" phenotype in adult cardiac muscle exhibits similarities to replicative senescence more generally and constitutes a barrier to effective restorative growth in heart disease. Telomere dysfunction is implicated in senescence and apoptotic signaling but its potential role in heart disorders is unknown. Here, we report that cardiac apoptosis in human heart failure is associated specifically with...

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Share to Genetics, Aging, and Longevity in Model Organisms
Share to Muscle Physiology and Disorders
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12702777
DOI: 10.1073/pnas.0836098100

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