Article
A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure.
Circulation - 21 Apr 2009
Jain Mohit, Jakubowski Aniela, Cui Lei, Shi Jianru, Su Lihe, Bauer Michael, Guan Jian, Lim Chee Chew, Naito Yoshiro, Thompson Jeffrey S, Sam Flora, Ambrose Christine, Parr Michael, Crowell Thomas, Lincecum John M, Wang Monica Z, Hsu Yen-Ming, Zheng Timothy S, Michaelson Jennifer S, Liao Ronglih, Burkly Linda C
Abstract excerpt
BACKGROUND: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, is a multifunctional cytokine known to regulate cellular functions in contexts of injury and disease through its receptor, fibroblast growth factor-inducible molecule 14 (Fn14). Although many of the processes and downstream signals regulated by the TWEAK/Fn14 pathway have been implicated in...
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