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Article

FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.

Molecular and cellular biology - 1 Dec 2004

Li Wei, Simarro Maria, Kedersha Nancy, Anderson Paul

Abstract excerpt

The Fas-activated serine/threonine phosphoprotein (FAST) is tethered to the outer mitochondrial membrane, where it interacts with BCL-X(L) (17). Here we show that RNA interference-mediated knockdown of endogenous FAST results in apoptosis, whereas overexpressed recombinant FAST inhibits Fas- and UV-induced apoptosis, indicating that FAST is a survival protein. The antiapoptotic effects of FAST are regulated by...

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Source

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Identifiers

PMID: 15572676
DOI: 10.1128/MCB.24.24.10718-10732.2004
PMCID: PMC533970

Genes

GAPDH
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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