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Article

Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2015

Wan Feng, Letavernier Emmanuel, Le Saux Claude Jourdan, Houssaini Amal, Abid Shariq, Czibik Gabor, Sawaki Daigo, Marcos Elisabeth, Dubois-Rande Jean-Luc, Baud Laurent, Adnot Serge, Derumeaux Geneviève, Gellen Barnabas

Abstract excerpt

The activation of the calpain system is involved in the repair process following myocardial infarction (MI). However, the impact of the inhibition of calpain by calpastatin, its natural inhibitor, on scar healing and left ventricular (LV) remodeling is elusive. Male mice ubiquitously overexpressing calpastatin (TG) and wild-type (WT) controls were subjected to an anterior coronary artery ligation. Mortality at 6...

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Identifiers

PMID: 26453333
DOI: 10.1152/ajpheart.00594.2015

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