Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tumor necrosis factor receptor-associated factor 2 signaling provokes adverse cardiac remodeling in the adult mammalian heart.

Circulation. Heart failure - 1 May 2013

Divakaran Vijay G, Evans Sarah, Topkara Veli K, Diwan Abhinav, Burchfield Jana, Gao Feng, Dong Jianwen, Tzeng Huei-Ping, Sivasubramanian Natarajan, Barger Philip M, Mann Douglas L

Abstract excerpt

BACKGROUND: Tumor necrosis factor superfamily ligands provoke a dilated cardiac phenotype signal through a common scaffolding protein termed tumor necrosis factor receptor-associated factor 2 (TRAF2); however, virtually nothing is known about TRAF2 signaling in the adult mammalian heart. METHODS AND RESULTS: We generated multiple founder lines of mice with cardiac-restricted overexpression of TRAF2 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Extracellular Matrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Microscopy, Electron, Transmission

Share to Muscle Cells

Share to NF-kappa B

Share to TNF Receptor-Associated Factor 2

Share to Ventricular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 23493088
DOI: 10.1161/CIRCHEARTFAILURE.112.000080
PMCID: PMC3672470

Genes

TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor necrosis factor receptor-associated factor 2 signaling provokes adverse cardiac remodeling in the adult mammalian heart.PMID 23493088Read ↗

Dysferlin mediates the cytoprotective effects of TRAF2 following myocardial ischemia reperfusion injury.Semantic proximity Read ↗

Targeted overexpression of transmembrane tumor necrosis factor provokes a concentric cardiac hypertrophic phenotype.Semantic proximity Read ↗

Selective disruption of MMP-2 gene exacerbates myocardial inflammation and dysfunction in mice with cytokine-induced cardiomyopathySemantic proximity Read ↗

Inflammation shapes pathogenesis of murine arrhythmogenic cardiomyopathy.Semantic proximity Read ↗

Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.Semantic proximity Read ↗

The development of myocardial fibrosis in transgenic mice with targeted overexpression of tumor necrosis factor requires mast cell-fibroblast interactions.Semantic proximity Read ↗

Mechanisms of Innate Immune Injury in Arrhythmogenic CardiomyopathySemantic proximity Read ↗

p38β/MAPK11 Deficiency Exacerbates Cardiac Structural and Electrophysiological Remodeling and Contributes to Immune Dysregulation in the Aging HeartSemantic proximity Read ↗

A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure.Semantic proximity Read ↗

Early cardiac inflammation as a driver of murine model of Arrhythmogenic CardiomyopathySemantic proximity Read ↗

Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice.Semantic proximity Read ↗

Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.