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Article

A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes

28 Jun 2016

Abstract excerpt

Antagonizing TNF-α signaling attenuates chronic inflammatory disease, but is associated with adverse effects on the cardiovascular system. Therefore the impact of TNF-α on basal control of redox signaling events needs to be understand in more depth. This is particularly important for the Keap1/Nrf2 pathway in the heart and in the present study we hypothesized that inhibition of a low level of TNF-α signaling...

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PMID: 27423013
DOI: 10.1016/j.redox.2016.06.004

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