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Article

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

Diabetes - 1 Jul 2014

Ferreira Ricardo C, Guo Hui, Coulson Richard M R, Smyth Deborah J, Pekalski Marcin L, Burren Oliver S, Cutler Antony J, Doecke James D, Flint Shaun, McKinney Eoin F, Lyons Paul A, Smith Kenneth G C, Achenbach Peter, Beyerlein Andreas, Dunger David B, Clayton David G, Wicker Linda S, Todd John A, Bonifacio Ezio, Wallace Chris, Ziegler Anette-G

Abstract excerpt

Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by the appearance of circulating autoantibodies to pancreatic islets. However, almost nothing is known about events leading to this islet autoimmunity. Previous epidemiological and genetic data have associated viral infections and antiviral type I interferon (IFN) immune response genes with T1D. Here, we first used DNA microarray analysis to...

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Source

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Identifiers

PMID: 24561305
DOI: 10.2337/db13-1777
PMCID: PMC4066333

Genes

IFIH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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