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Potential role of type I interferon in the pathogenic process leading to type 1 diabetes

24 Jan 2018

Abstract excerpt

PURPOSE OF REVIEW: Understanding the relationship between viral infections and the development of type 1 diabetes (T1D) is essential for T1D prevention. Virus-induced innate immune responses, specifically type I interferon (IFN-I) and the IFN gene signature, orchestrate early events of β-cell dysfunction preceding islet autoimmunity. We summarize recent advances in how IFN-I and the IFN gene signature can drive...

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PMID: 29369915
DOI: 10.1097/med.0000000000000399

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