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Article

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.

Diabetes - 1 Jul 2014

Kallionpää Henna, Elo Laura L, Laajala Essi, Mykkänen Juha, Ricaño-Ponce Isis, Vaarma Matti, Laajala Teemu D, Hyöty Heikki, Ilonen Jorma, Veijola Riitta, Simell Tuula, Wijmenga Cisca, Knip Mikael, Lähdesmäki Harri, Simell Olli, Lahesmaa Riitta

Abstract excerpt

The insult leading to autoantibody development in children who will progress to develop type 1 diabetes (T1D) has remained elusive. To investigate the genes and molecular pathways in the pathogenesis of this disease, we performed genome-wide transcriptomics analysis on a unique series of prospective whole-blood RNA samples from at-risk children collected in the Finnish Type 1 Diabetes Prediction and Prevention...

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Share to Autoantibodies
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

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Source

Identifiers

PMID: 24550192
DOI: 10.2337/db13-1775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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