Article
Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes.
BMC genetics - 22 Feb 2006
Morris Gerard A J, Lowe Christopher E, Cooper Jason D, Payne Felicity, Vella Adrian, Godfrey Lisa, Hulme John S, Walker Neil M, Healy Barry C, Lam Alex C, Lyons Paul A, Todd John A
Abstract excerpt
BACKGROUND: The aetiology of the autoimmune disease type 1 diabetes (T1D) involves many genetic and environmental factors. Evidence suggests that innate immune responses, including the action of interferons, may also play a role in the initiation and/or pathogenic process of autoimmunity. In the present report, we have adopted a linkage disequilibrium (LD) mapping approach to test for an association between T1D...
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