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Article

Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression.

Science translational medicine - 31 Mar 2021

Xhonneux Louis-Pascal, Knight Oliver, Lernmark Åke, Bonifacio Ezio, Hagopian William A, Rewers Marian J, She Jin-Xiong, Toppari Jorma, Parikh Hemang, Smith Kenneth G C, Ziegler Anette-G, Akolkar Beena, Krischer Jeffrey P, McKinney Eoin F

Abstract excerpt

Type 1 diabetes (T1D) is a disease of insulin deficiency that results from autoimmune destruction of pancreatic islet β cells. The exact cause of T1D remains unknown, although asymptomatic islet autoimmunity lasting from weeks to years before diagnosis raises the possibility of intervention before the onset of clinical disease. The number, type, and titer of islet autoantibodies are associated with long-term...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33790023
DOI: 10.1126/scitranslmed.abd5666
PMCID: PMC8447843

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