Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age-dependent gene expression trajectories during early childhood in children at increased risk for type 1 diabetes.

Genes and immunity - 1 Apr 2025

Zeller Ivo, Weiss Andreas, Hummel Sandra, Ziegler Anette-Gabriele, Bonifacio Ezio

Abstract excerpt

Early childhood is a period of rapid growth and immune system development. It is also critical for type 1 diabetes (T1D) autoimmunity, which has a peak incidence between 1 and 2 years of age. Here, we investigated age-related longitudinal gene expression changes in peripheral blood mononuclear cells from children aged 3 months to 3 years who had an increased genetic risk for T1D, aiming to delineate gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Autoimmunity
Share to Child, Preschool

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Genetic Predisposition to Disease

Share to Infant

Share to Leukocytes, Mononuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 40113970
DOI: 10.1038/s41435-025-00324-8
PMCID: PMC12006016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-dependent gene expression trajectories during early childhood in children at increased risk for type 1 diabetes.PMID 40113970Read ↗

Transcriptional networks in at-risk individuals identify signatures of type 1 diabetes progression.Semantic proximity Read ↗

Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling.Semantic proximity Read ↗

Risk of Type 1 Diabetes Progression in Islet Autoantibody-Positive Children Can Be Further Stratified Using Expression Patterns of Multiple Genes Implicated in Peripheral Blood Lymphocyte Activation and FunctionSemantic proximity Read ↗

Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility.Semantic proximity Read ↗

Longitudinal DNA methylation differences precede type 1 diabetesSemantic proximity Read ↗

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.Semantic proximity Read ↗

Evolving epigenomics of immune cells in type 1 diabetes at single nuclei resolutionSemantic proximity Read ↗

Gene expression signature predicts rate of type 1 diabetes progressionSemantic proximity Read ↗

Early DNA methylation changes in children developing beta cell autoimmunity at a young ageSemantic proximity Read ↗

Gene Expression in Peripheral Blood Mononuclear Cells from Children with DiabetesSemantic proximity Read ↗

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.Semantic proximity Read ↗

Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.