Article

Interferons are the key cytokines acting on pancreatic islets in type 1 diabetes

2023-07-01

Abstract excerpt

The pro-inflammatory cytokines IFNα, IFNγ, IL-1β and TNFα may contribute to innate and adaptive immune responses during islet inflammation (insulitis) in type 1 diabetes (T1D). We used deep RNA-sequencing analysis to characterize the response of human pancreatic beta cells to each cytokine individually and compared the signatures obtained with those present in islets of individuals affected by T1D. IFNα and IFNγ h...

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Literature Corpus work: cbad280c-59c7-5e53-ae59-6a384da0de8f
DOI: 10.1101/2023.06.29.547000

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