Article
Fine-mapping the HOXB region detects common variants tagging a rare coding allele: evidence for synthetic association in prostate cancer.
PLoS genetics - 1 Feb 2014
Saunders Edward J, Dadaev Tokhir, Leongamornlert Daniel A, Jugurnauth-Little Sarah, Tymrakiewicz Malgorzata, Wiklund Fredrik, Al Olama Ali Amin, Benlloch Sara, Neal David E, Hamdy Freddie C, Donovan Jenny L, Giles Graham G, Severi Gianluca, Gronberg Henrik, Aly Markus, Haiman Christopher A, Schumacher Fredrick, Henderson Brian E, Lindstrom Sara, Kraft Peter, Hunter David J, Gapstur Susan, Chanock Stephen, Berndt Sonja I, Albanes Demetrius, Andriole Gerald, Schleutker Johanna, Weischer Maren, Nordestgaard Børge G, Canzian Federico, Campa Daniele, Riboli Elio, Key Tim J, Travis Ruth C, Ingles Sue A, John Esther M, Hayes Richard B, Pharoah Paul, Khaw Kay-Tee, Stanford Janet L, Ostrander Elaine A, Signorello Lisa B, Thibodeau Stephen N, Schaid Daniel, Maier Christiane, Kibel Adam S, Cybulski Cezary, Cannon-Albright Lisa, Brenner Hermann, Park Jong Y, Kaneva Radka, Batra Jyotsna, Clements Judith A, Teixeira Manuel R, Xu Jianfeng, Mikropoulos Christos, Goh Chee, Govindasami Koveela, Guy Michelle, Wilkinson Rosemary A, Sawyer Emma J, Morgan Angela, Easton Douglas F, Muir Ken, Eeles Rosalind A, Kote-Jarai Zsofia
Abstract excerpt
The HOXB13 gene has been implicated in prostate cancer (PrCa) susceptibility. We performed a high resolution fine-mapping analysis to comprehensively evaluate the association between common genetic variation across the HOXB genetic locus at 17q21 and PrCa risk. This involved genotyping 700 SNPs using a custom Illumina iSelect array (iCOGS) followed by imputation of 3195 SNPs in 20,440 PrCa cases and 21,469...
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