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Article

Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk.

European urology - 1 Aug 2021

Darst Burcu F, Sheng Xin, Eeles Rosalind A, Kote-Jarai Zsofia, Conti David V, Haiman Christopher A

Abstract excerpt

Although prostate cancer is known to have a strong genetic basis and is influenced by both common and rare variants, the ability to investigate the combined effect of such genetic risk factors has been limited to date. We conducted an investigation of 81 094 men from the UK Biobank, including 3568 prostate cancer cases, to examine the combined effect of rare pathogenic/likely pathogenic/deleterious (P/LP/D)...

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Source

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Identifiers

PMID: 33941403
DOI: 10.1016/j.eururo.2021.04.013
PMCID: PMC8286329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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