Article
HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG).
Human genetics - 1 Jan 2013
Xu Jianfeng, Lange Ethan M, Lu Lingyi, Zheng Siqun L, Wang Zhong, Thibodeau Stephen N, Cannon-Albright Lisa A, Teerlink Craig C, Camp Nicola J, Johnson Anna M, Zuhlke Kimberly A, Stanford Janet L, Ostrander Elaine A, Wiley Kathleen E, Isaacs Sarah D, Walsh Patrick C, Maier Christiane, Luedeke Manuel, Vogel Walther, Schleutker Johanna, Wahlfors Tiina, Tammela Teuvo, Schaid Daniel, McDonnell Shannon K, DeRycke Melissa S, Cancel-Tassin Geraldine, Cussenot Olivier, Wiklund Fredrik, Grönberg Henrik, Eeles Ros, Easton Doug, Kote-Jarai Zsofia, Whittemore Alice S, Hsieh Chih-Lin, Giles Graham G, Hopper John L, Severi Gianluca, Catalona William J, Mandal Diptasri, Ledet Elisa, Foulkes William D, Hamel Nancy, Mahle Lovise, Moller Pal, Powell Isaac, Bailey-Wilson Joan E, Carpten John D, Seminara Daniela, Cooney Kathleen A, Isaacs William B
Abstract excerpt
Prostate cancer has a strong familial component but uncovering the molecular basis for inherited susceptibility for this disease has been challenging. Recently, a rare, recurrent mutation (G84E) in HOXB13 was reported to be associated with prostate cancer risk. Confirmation and characterization of this finding is necessary to potentially translate this information to the clinic. To examine this finding in a large...
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