Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes.

doi:10.1093/annonc/mdv004

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Article

Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Apr 2015

Kote-Jarai Z, Mikropoulos C, Leongamornlert D A, Dadaev T, Tymrakiewicz M, Saunders E J, Jones M, Jugurnauth-Little S, Govindasami K, Guy M, Hamdy F C, Donovan J L, Neal D E, Lane J A, Dearnaley D, Wilkinson R A, Sawyer E J, Morgan A, Antoniou A C, Eeles R A

Abstract excerpt

BACKGROUND: A rare recurrent missense variant in HOXB13 (rs138213197/G84E) was recently reported to be associated with hereditary prostate cancer. Population-based studies have established that, since the frequency of this single-nucleotide polymorphism (SNP) varies between geographic regions, the associated proportion of prostate cancer (PrCa) risk contribution is also highly variable by country. PATIENTS AND...

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PMID: 25595936
DOI: 10.1093/annonc/mdv004

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HOXB13

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