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Germline Mutations in HOXB13 and Prostate-Cancer Risk

11 Jan 2012

Abstract excerpt

BACKGROUND: Family history is a significant risk factor for prostate cancer, although the molecular basis for this association is poorly understood. Linkage studies have implicated chromosome 17q21-22 as a possible location of a prostate-cancer susceptibility gene. METHODS: We screened more than 200 genes in the 17q21-22 region by sequencing germline DNA from 94 unrelated patients with prostate cancer from...

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PMID: 22236224
DOI: 10.1056/nejmoa1110000

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