Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer.

doi:10.1093/hmg/ddr189

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Article

Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer.

Human molecular genetics - 15 Jul 2011

Chung Charles C, Ciampa Julia, Yeager Meredith, Jacobs Kevin B, Berndt Sonja I, Hayes Richard B, Gonzalez-Bosquet Jesus, Kraft Peter, Wacholder Sholom, Orr Nick, Yu Kai, Hutchinson Amy, Boland Joseph, Chen Quan, Feigelson Heather Spencer, Thun Michael J, Diver W Ryan, Albanes Demetrius, Virtamo Jarmo, Weinstein Stephanie, Schumacher Fredrick R, Cancel-Tassin Geraldine, Cussenot Olivier, Valeri Antoine, Andriole Gerald L, Crawford E David, Haiman Christopher A, Henderson Brian E, Kolonel Laurence, Le Marchand Loic, Siddiq Afshan, Riboli Elio, Key Tim J, Kaaks Rudolf, Isaacs William B, Isaacs Sarah D, Grönberg Henrik, Wiklund Fredrik, Xu Jianfeng, Vatten Lars J, Hveem Kristian, Njolstad Inger, Gerhard Daniela S, Tucker Margaret, Hoover Robert N, Fraumeni Joseph F, Hunter David J, Thomas Gilles, Chatterjee Nilanjan, Chanock Stephen J

Abstract excerpt

Genome-wide association studies have identified prostate cancer susceptibility alleles on chromosome 11q13. As part of the Cancer Genetic Markers of Susceptibility (CGEMS) Initiative, the region flanking the most significant marker, rs10896449, was fine mapped in 10 272 cases and 9123 controls of European origin (10 studies) using 120 common single nucleotide polymorphisms (SNPs) selected by a two-staged tagging...

Topics

Case-Control Studies
Chromosome Mapping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Chromosomes, Human, Pair 11

Genetic Loci

Genetic Predisposition to Disease

Genome-Wide Association Study

Humans

Linkage Disequilibrium

Male

Polymorphism, Single Nucleotide

Prostatic Neoplasms

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21531787
DOI: 10.1093/hmg/ddr189
PMCID: PMC3118760

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