Association of HOXB13 G84E With Prostate Cancer Among 592,158 Men.

doi:10.6004/jnccn.2025.7055

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Article

Association of HOXB13 G84E With Prostate Cancer Among 592,158 Men.

Journal of the National Comprehensive Cancer Network : JNCCN - 15 Sept 2025

Crawford Taylor B, Nelson Tyler, Karunamuni Roshan, Desai Heena, Hausler Ryan, Teerlink Craig, Carter Hannah, Pagadala Meghana S, Alba Patrick R, DuVall Scott L, Danowski Morgan E, Brunette Charles A, Ratner Dmitry, Garraway Isla P, Rose Brent S, Smith Jeffrey R, Cooney Kathleen A, Vassy Jason L, Hauger Richard L, Lynch Julie A, Seibert Tyler M, Maxwell Kara N

Abstract excerpt

BACKGROUND: The HOXB13 c.G251G>A:p.G84E (rs138213197) variant is associated with an increased risk of prostate cancer (PrCa); however, its link to aggressive PrCa remains controversial. Limited data from large, population-based cohorts are available to inform genetic counseling and clarify the PrCa risk associated with this variant. PATIENTS AND METHODS: We identified individuals heterozygous for HOXB13 p.G84E or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40953603
DOI: 10.6004/jnccn.2025.7055

Genes

HOXB13
MVP

Variants

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