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Fine mapping of 11q13.5 identifies regions associated with prostate cancer and prostate cancer death.

European journal of cancer (Oxford, England : 1990) - 1 Oct 2013

Nurminen Riikka, Lehtonen Rainer, Auvinen Anssi, Tammela Teuvo L J, Wahlfors Tiina, Schleutker Johanna

Abstract excerpt

BACKGROUND: Chromosomal region 11q13-14 associates with prostate cancer (PrCa). Previously, we identified a rare intronic mutation on EMSY (11q13.5) that increases the risk of aggressive PrCa and associates with familial PrCa. Here, we further study the genetic structure and variants of the PrCa susceptibility region 11q13.5. METHODS: This study included 2716 unselected hospital-based PrCa cases, 1318 cases of a...

Topics

Adult
Aged
Aged, 80 and over
Chromosome Mapping
Chromosomes, Human, Pair 11
Finland
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Single Nucleotide

Prostatic Neoplasms

Risk Factors

Source

Identifiers

PMID: 23830236
DOI: 10.1016/j.ejca.2013.06.006

Genes

EMSY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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