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The SNF2‐like helicase HELLS mediates E2F3‐dependent transcription and cellular transformation

13 Dec 2011

Abstract excerpt

The activating E2F-transcription factors are best known for their dependence on the Retinoblastoma protein and their role in cellular proliferation. E2F3 is uniquely amplified in specific human tumours where its expression is inversely correlated with the survival of patients. Here, E2F3B interaction partners were identified by mass spectrometric analysis. We show that the SNF2-like helicase HELLS interacts with...

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PMID: 22157815
DOI: 10.1038/emboj.2011.451

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