Article

cMYC protein interactions and chromatin association in NUT carcinoma

2022-04-22

Abstract excerpt

The oncogene c MYC (HGNC:7553) is a critical genomic target of the BRD4-NUT (B4N) protein that defines many of the NUTM1-rearrangement cancer subtypes in NUT carcinoma (NC). Previously, we reported that B4N interacts with the EP300 lysine acetyltransferase (KAT3B) and creates hyperacetylated “megadomains” that activate downstream genes such as cMYC . Here we ask how misregulated cMYC in turn interacts with prote...

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Literature Corpus work: 59d62982-5745-5c28-b9ca-bea1d4a54999
DOI: 10.1101/2022.04.22.489219

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