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Article

Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.

Expert review of proteomics - 1 Jun 2015

Katoh Masaru

Abstract excerpt

ASXL1, ASXL2 and ASXL3 are epigenetic scaffolds for BAP1, EZH2, NCOA1, nuclear receptors and WTIP. Here, functional proteomics of the ASXL family members are reviewed with emphasis on mutation spectra, the ASXM2 domain and the plant homeodomain (PHD) finger. Copy number gains of ASXL1 occur in chromosome 20q11.2 duplication syndrome and cervical cancer. Truncation mutations of ASXLs occur in autism, Bohring-Opitz...

Read the complete abstract on PubMed

Topics

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Share to Epigenesis, Genetic
Share to BAP1 gene
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Structure, Tertiary

Share to Proteomics

Share to Repressor Proteins

Share to Transcription Factors

Share to Translational Research, Biomedical

Source

Identifiers

PMID: 25835095
DOI: 10.1586/14789450.2015.1033409

Genes

ASXL1
ASXL2
ASXL3
WTIP
BAP1
BPTF
ING1
NCOA1
PHF2
PHF23
PHF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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