Article

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 using Proximity Labeling and Affinity Purification

2022-09-19

Abstract excerpt

<h4>ABSTRACT</h4> The DNA repair scaffold SLX4 has pivotal roles in cellular processes that maintain genome stability, most notably homologous recombination. Germline mutations in SLX4 are associated with Fanconi anemia, a disease characterized by chromosome instability and cancer susceptibility. The role of mammalian SLX4 in homologous recombination depends critically on binding and activating structure-selecti...

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Literature Corpus work: 80d0f6b6-2a19-56ea-8531-100599f04de1
DOI: 10.1101/2022.09.19.508447

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