Article
Rat1p maintains RNA polymerase II CTD phosphorylation balance.
RNA (New York, N.Y.) - 1 Apr 2014
Jimeno-González Silvia, Schmid Manfred, Malagon Francisco, Haaning Line Lindegaard, Jensen Torben Heick
Abstract excerpt
In S. cerevisiae, the 5'-3' exonuclease Rat1p partakes in transcription termination. Although Rat1p-mediated RNA degradation has been suggested to play a role for this activity, the exact mechanisms by which Rat1p helps release RNA polymerase II (RNAPII) from the DNA template are poorly understood. Here we describe a function of Rat1p in regulating phosphorylation levels of the C-terminal domain (CTD) of the...
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