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Article

The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses.

PloS one - 1 Jan 2011

Poschmann Jeremie, Drouin Simon, Jacques Pierre-Etienne, El Fadili Karima, Newmarch Michael, Robert François, Ramotar Dindial

Abstract excerpt

Rapamycin is an anticancer agent and immunosuppressant that acts by inhibiting the TOR signaling pathway. In yeast, rapamycin mediates a profound transcriptional response for which the RRD1 gene is required. To further investigate this connection, we performed genome-wide location analysis of RNA polymerase II (RNAPII) and Rrd1 in response to rapamycin and found that Rrd1 colocalizes with RNAPII on actively...

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Identifiers

PMID: 21887235
DOI: 10.1371/journal.pone.0023159
PMCID: PMC3160861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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