Article
Pristane-induced arthritis loci interact with the Slc11a1 gene to determine susceptibility in mice selected for high inflammation.
PloS one - 1 Jan 2014
De Franco Marcelo, Peters Luciana C, Correa Mara A, Galvan Antonella, Canhamero Tatiane, Borrego Andrea, Jensen José R, Gonçalves Jussara, Cabrera Wafa H K, Starobinas Nancy, Ribeiro Orlando G, Dragani Tommaso A, Dragani Tommaso, Ibañez Olga M
Abstract excerpt
AIRmax (maximal inflammation) and AIRmin (minimal inflammation) mice show distinct susceptibilities to pristane-induced arthritis (PIA). The Slc11a1 gene, which regulates macrophage and neutrophil activity, is involved in this infirmity. AIRmax (SS) mice homozygous for the non-functional Slc11a1 S (gly169asp) allele obtained by genotype-assisted crosses from AIRmax and AIRmin mice are more susceptible than mice...
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